This Blog has more than thousand Powerpoint presentations of various departments related to pharma

"This Blog has more than 1000 Powerpoint presentations of various departments related to pharmacy and Medical" Thank You for Visiting

Translate

SCIENTIFIC AND TECHNICAL WRITING




Course Objectives: 
            To be able to appreciate and understand importance of writing scientifically.
            To develop competence in writing and abstracting skills.
            To write either a draft research proposal or a chapter of dissertation.


COLLECTION AND EVALUATION OF INFORMATION
Identification, sources, searching information, classifying information under fact/opinion, tabulating information, summarizing a text and presenting sequence of topics in different forms.

 WRITING AS A MEANS OF COMMUNICATION
-  Different forms of scientific and technical writing.
- Articles in journals, research notes and reports, review articles, monographs, dissertations, bibliographies.
How to formulate outlines: The reasons for preparing outlines
            as a guide for plan of writing
            as skeleton for the manuscript

Kinds of outline: topic outlines, conceptual outline, sentence outlines and combination of topic and sentence outlines

DRAFTING TITLES, SUB TITLES, TABLES, ILLUSTRATIONS
Tables as systematic means of presenting data in rows and columns and lucid way of indicating relationships and results.
Formatting Tables: Title, Body stab, Stab Column, Column Head, Spanner Head, Box Head
Appendices: use and guidelines.
The Writing process: Getting started, Use outline as a starting device, Drafting, Reflecting and Re-reading. Checking: Organization, Headings, Content, Clarity and Grammar.
Brevity and Precision in writing - Drafting and Re-drafting based on critical evaluation

 PARTS OF DISSERTATION/RESEARCH REPORT/ARTICLE
Introduction, Review of Literature, Methodology, Results and Discussion. Ask questions related to: content, continuity, clarify, validity internal consistency and objectivity during writing each of the above parts.

WRITING FOR GRANTS
            - Clearly state the question to be addressed
            - Rationale and importance of the question being address
            - Emperial and theoretical conceptualization
            - Presenting pilot study/data
            - Research proposal, clarity, specificity of method
            - Clear organization
            - Outcome of study and its implications 
            - Budgeting, available infra-structure and recourses

PHARMACEUTICAL PRODUCTION TECHNOLOGY



Improved  Tablet  Production:   Tablet production process, unit operation improvements, granulation and pelletization equipments, continuous and batch mixing, rapid mixing granulators, rota granulators, speronizers and marumerisers, and other specialized granulation and drying equipments.  Problems encountered. 
Coating Technology:    Process, equipments, particle coating, fluidized bed coating, application techniques.   Problems encountered. 
  
Parenteral  Production:      Area planning & environmental control, wall and floor treatment, fixtures and machineries, change rooms, personnel flow, utilities & utilities equipment location, engineering and maintenance. 
Lyophilization Technology:  Principles, process, freeze-drying equipments.   
  
Capsule Production:   Production process, improved capsule manufacturing and filling machines for hard and soft gelatin capsules.  Layout and problems encountered. 
Disperse Systems Production:  Production processes, applications of mixers, mills, disperse equipments including fine solids dispersion,   problems encountered.  
  
Packaging  Technology:    Types of packaging materials, machinery, labeling, package printing for different dosage forms.   

Air Handling Systems:  Study of AHUs, humidity & temperature control, air filtration systems, dust collectors. 

PHARMACEUTICAL PRODUCT DEVELOPMENT



Preformulation Studies: Molecular optimization of APIs (drug substances), crystal morphology and variations, powder flow, structure modification, drug-excipient compatibility studies, methods of determination.


Formulation Additives: Study of different formulation additivies, factors influencing their incorporation, role of formulation development and processing, new developments in excipient science, determination methods, drug excipient interactions.  Design of experiments – factorial design for product and process development. 


Solubility: Importance, experimental determination, phase-solubility analysis, pH-solubility profile, solubility techniques to improve solubility and utilization of analytical methods – cosolvency, salt formation, complexation, solid dispersion, micellar solubilization and hydrotropy. 


Dissolution: Theories, mechanisms of dissolution, in-vitro dissolution testing models – sink and non-sink. Factors influencing dissolution and intrinsic dissolution studies. Dissolution test apparatus – designs, dissolution testing for conventional and controlled release products.  Data handling and correction factor. Biorelevent media, in-vitro and in-vivo correlations, levels of correlations.


Product Stability: Degradation kinetics, mechanisms, stability testing of drugs and pharmaceuticals, factors influencing-media effects and pH effects, accelerated stability studies, interpretation of kinetic data (API & tablets). Solid state stability and shelf life assignment. Stability protocols, reports and ICH guidelines. 

BIOPHARMACEUTICS AND PHARMACOKINETICS



Bioavailability and Bioquiovalence:   Objectives, bioavailability & variations, measurements of bioavailability, enhancing bioavailability, concepts of equivalents, official bioequivalence protocols & therapeutic equivalence. 
 
Drug Absorption:  General consideration, absorption / drug transport mechanisms, role factors affecting absorption, absorption of drug non-peroral routes, methods of determining absorption-in-vitro, in-situ, and in-vivo methods. 
Drug Distribution:  Factors affecting, protein & tissue binding, kinetics, determination of rate constants & different plots (direct, Scatchard, & reciprocal). 

Pharmacokinetcs:    Parameters & determination, pharmacokinetic models – one compartment, multi compartment in IV bolus, IV infusion & extra vascular, drug & metabolites levels in blood, urine and other 
biological fluids.  Integration of kinetics. 
Application of pharmacokinetics in new drug development, design of dosage forms and novel drug delivery systems.   

Drug Disposition and Excretion:   Biotransformation,  factors  affecting biotrasformation, Phase I &  Phase-II reactions. 
Clearance:  Concept, renal, non-renal clearance, mechanism, determination, % drug metabolized, different volume of distribution.   

Pharmacokinetics of Multiple Dosing:   Various terminology, determination, adjustment of dosage in renal & hepatic impairment, individualization of therapy, therapeutic drug monitoring. 
Non-linear kinetics:   Cause of non-linearity, estimation of various parameters, bioavailability of drugs that follow non-linear kinetics. Chronopharmacokinetics & pharmacokinetics of elderly and infants. 

Wikipedia

Search results