Bioavailability and Bioquiovalence: Objectives, bioavailability &
variations, measurements of bioavailability, enhancing bioavailability,
concepts of equivalents, official bioequivalence protocols & therapeutic
equivalence.
Drug Absorption: General consideration, absorption / drug
transport mechanisms, role factors affecting absorption, absorption of
drug non-peroral routes, methods of determining absorption-in-vitro, in-situ,
and in-vivo methods.
Drug Distribution: Factors affecting, protein & tissue
binding, kinetics, determination of rate constants & different plots
(direct, Scatchard, & reciprocal).
Pharmacokinetcs: Parameters & determination,
pharmacokinetic models – one compartment, multi compartment in IV bolus, IV
infusion & extra vascular, drug & metabolites levels in blood, urine
and other
biological fluids. Integration of kinetics.
Application of pharmacokinetics in
new drug development, design of dosage forms and novel drug delivery
systems.
Drug Disposition and
Excretion: Biotransformation, factors
affecting biotrasformation, Phase I & Phase-II reactions.
Clearance: Concept, renal, non-renal clearance,
mechanism, determination, % drug metabolized, different volume of
distribution.
Pharmacokinetics of Multiple
Dosing: Various terminology,
determination, adjustment of dosage in renal & hepatic impairment,
individualization of therapy, therapeutic drug monitoring.
Non-linear kinetics: Cause of non-linearity, estimation of
various parameters, bioavailability of drugs that follow non-linear kinetics.
Chronopharmacokinetics & pharmacokinetics of elderly and infants.