Principles of Pharmacokinetics.
A. Revision of Basic concepts.
B. Clinical Pharmacokinetics.
1. Dose – response in man
2. Influence of renal and hepatic disease on
Pharmacokinetics
3. Therapeutics drug monitoring
4. Population Pharmacokinetics.
Basics in clinical pharmacology
Clinical trials of drugs,design
of clinical trials
Therapeutic drug monitoring and
critieria for TDM.
Adverse Drug Reactions, Drug Interactions
and ADR monitoring.
Pathophysiology
and drug therapy of the following disorders.
Schizophrenia, anxiety, depression, epilepsy,
Parkinson’s Alzheimer’s diseases Migraine hypertension, angina pectoris,
arrhythmias, atherosclerosis, myocardial infraction, TB, leprosy, leukemia,
solid tumors, lymphomas, psoriasis, respiratory, urinary , g.i. tract
infections, endocarditic, fungal and HIV infection, rheumatoid arthritis,
glaucoma, menstrual disorders, menopause.
Drug therapy and Pharmacokinetics in
a. Geriatrics
b. Pediatrics
c. Pregnancy & Lactation.
Pharmacogenetics:
Historical aspects of pharmacogenetics, biomarkers, inter-racial and individual
variability in drugs metabolism., receptors .Role of drug transporters,
interethnic differences, clinical view points and future perspectives, stem
cell – a new therapeutic approach. Gene therapy, Pharmacovigilance concepts and
its impact.