Concept
& Models for NDDS: Classification of rate controlled drug delivery systems
(DDS), rate programmed release, activation modulated & feedback regulated
DDS, effect of system parameters in
controlled drug delivery, computation of desired release rate and dose for
controlled release DDS, pharmacokinetic design for DDS – intermittent, zero
order & first order release.
Carriers
for Drug Delivery: Polymers / co-polymers-introduction,
classification, characterization, polymerization techniques, application in
CDDS / NDDS, biodegradable & natural polymers.
Study
of Various DDS: Concepts, design, formulation & evaluation of
controlled release oral DDS, Mucoadhesive DDS (buccal, nasal, pulmonary).
Transdermal
Drug Delivery Systems: Theory, design, formulation & evaluation including
iontophoresis and other latest developments in skin delivery systems.
Advances
in Drug Delivery: Pulsatile, colon specific, liquid sustained release
systems.
Targeted
Drug Delivery Systems: Importance, concept, biological process and events
involved in drug targeting, design, formulation & evaluation, methods in
drug targeting – nanoparticles, liposomes, niosomes, pharmacosomes, resealed
erythorocytes, microspheres, magnetic microspheres. Specialized pharmaceutical emulsions –
multiple emulsions, micro-emulsions.
Protein
/ Peptide Drug Delivery Systems: Concepts, delivery techniques, formulation,
stability testing, causes of protein destabilization, stability and
destabilization.
Biotechnology
in Drug Delivery Systems: Brief review of major areas-recombinant DNA
technology, monoclonal antibodies, gene therapy.