Basic
Considerations of Drug Activity
Physico
chemical properties of drug molecules in relation to biological activity -
Solubility, lipophilicity, partition-coefficient, Ionization, hydrogen bonding,
Chelation, Redox potential and Surface activity. Bioisosterism and Steric
features of drugs, drug distribution and protein binding; Introduction to Pro
and Soft drug approach in drug design; Drug metabolism and factors affecting on
drug metabolism
Adrenergic agents
- (Isoproterenol and Salbutamol)
Adrenergic blocking agents - (Prazocin and Atenatol)
Cholinergic
drugs and Acetyl Choline esterase inhibitors - (Carbachol, Physostigmine).
Cholinergic blocking agents - (Pyridinium bromide and Dicyclomine HCI)
Ganglionic
blocking agents and neuromuscular blocking agents -(Mecamylamine HCI and
Pentolinium Tartarate). Skeletal muscle relaxants -Neuromuscular -
(meprobromate)
Cardio
Vascular Drugs - Anti-hypertensive drugs - (Captopril and Clonidine)
Anti-arrhythmic drugs - (Verapamil, Nifedipine and Diltiazem),
Vasodilators
- (Isosorbide dinitrate and Dipyridamole)
Anti-
hyper lipidemic agents - (Clofibrate and Aterostatin)
Anti-platelet
drugs - (Aspirin and Ticlopidine)
Cardiao
tonic Agents - Synthetic analogs of cardiac glycosides
Diuretics
- (Acetazolamide and Furosemide, Hydrochlorthiazide and Amiloride).
Positive
Inotropic Agents (Amrinone)
Hypoglycemic
agents - (Tolbutamide and Glyclazide).
Thyroid
agents, Anti-thyroid gents -. (Prophylthiouracil)
Immuno
suppressants - (Azathioprine) and Immunostimulants -(Levamisole)
Anti-histaminics
(HI & H2)-(Diphenhydramine, Chlorpheniramine, Citrizine, Ranitidine).
Proton Pump Initiators (Omeprazole)
Coagulants
and Anti-coagulants - (Warfarin)