Synthetic
Reagents and Applications: Lead tetra
acetate (LTA), n-bromo succinamide (NBS), osmonium tetraoxide, lithium
aluminium hydride (LAH), sodium borohydride, DCC (Dicyclohexyl carbodimide),
and 2,3-dichlro-5,6-dicyano-1,4-benzoquinone (DDQ).
Mechanism
and applications of reactions and reagents:
a. Claisen ester condensation,
b. Mannich reaction,
c. Micheal addition,
d. Witting reaction,
e. Synthetic applications of ethyl aceto acetate, diethyl
malonate, ethylcyano acetate.
Development
& scale up of process for the manufacture of new pharmaceuticals:
1. Introduction, synthetic route selection, development
and scale up, optimization of synthetic routes-yield improvement, investigative
approach, streamlining the process.
2. A brief account on Green Chemistry: principles, and
applications.
Synthetic
Strategies: Introduction to
disconnection approach, consecutive vs convergent synthesis, various strategic
approaches in retro synthesis, strategic bond approach-preliminary scan,
criteria in disconnection of strategic bonds, identifying strategic bonds in
rings.
Combinatorial
Chemistry: Introduction, solid phase
techniques, parallel synthesis, mixed combinatorial chemistry, deconvulution
techniques, tagging, photolithography, limitations of combinatorial chemistry,
planning and designing of combinatorial synthesis.