Pharmacokinetics
approach to New Drug Discovery
Basic concepts and Defination, importance of ADME
parameters in disposition, therapeutics and development their implication on
drug discovery.
Overview on computer aided Drug design (CADD)
including QSAR, Combinational
Chemistry, High Throughout screening (RTS)
Molecular Basis of Drugs Action: Cell signaling,
communication between cells and their environment, ion-channels, organizations
of signal transduction pathways, third messengers, biosensors.
Drug Latentiation :Basic concept, Prodrugs of functional groups, Bio-precurssor
prodrugs, chemical delivery system.
Biotechnology in Drug Discovery: Cloning of DNA,
Expression of cloned DNA, Manipulation of DNA sequence information, New
Biological Targets for Drug Development Novel Drug Screening strategies, Novel
Biological Agents, Antibodies, Antisense eligonucleotide therapy, Gene therapy.
Herbal
Neutracauticals as new source for medicines.
Study
of Advanced drugs from natural sources of following groups:
Anticancer,
Anti AIDS, Hepatoprotectives, Antidiabetics, Brain Toni cs, Anti urolithiates,
Antifilarial, Antihyperlipidimics.
Modern phytochemical screening techniques and
evaluation of herbal drugs and
their extracts and formulations, Concept of Reverse
Pharmacognosy.