This Blog has more than thousand Powerpoint presentations of various departments related to pharma

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BIOPHARMACEUTICS AND PHARMACOKINETICS



Bioavailability and Bioquiovalence:   Objectives, bioavailability & variations, measurements of bioavailability, enhancing bioavailability, concepts of equivalents, official bioequivalence protocols & therapeutic equivalence. 
 
Drug Absorption:  General consideration, absorption / drug transport mechanisms, role factors affecting absorption, absorption of drug non-peroral routes, methods of determining absorption-in-vitro, in-situ, and in-vivo methods. 

Drug Distribution:  Factors affecting, protein & tissue binding, kinetics, determination of rate constants & different plots (direct, Scatchard, & reciprocal). 
 

Pharmacokinetcs:    Parameters & determination, pharmacokinetic models – one compartment, multi compartment in IV bolus, IV infusion & extra vascular, drug & metabolites levels in blood, urine and other 
biological fluids.  Integration of kinetics. 
Application of pharmacokinetics in new drug development, design of dosage forms and novel drug delivery systems. 
 
Drug Disposition and Excretion:   Biotransformation,  factors  affecting biotrasformation, Phase I &  Phase-II reactions. 
Clearance:  Concept, renal, non-renal clearance, mechanism, determination, % drug metabolized, different volume of distribution. 
 
Pharmacokinetics of Multiple Dosing:   Various terminology, determination, adjustment of dosage in renal & hepatic impairment, individualization of therapy, therapeutic drug monitoring. 
Non-linear kinetics:   Cause of non-linearity, estimation of various parameters, bioavailability of drugs that follow non-linear kinetics. Chronopharmacokinetics & pharmacokinetics of elderly and infants. 

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